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Ascentage Pharma Group InternationalIncome Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $334.13M ▲ | $906.3M ▲ | $-639.96M ▼ | -191.53% ▲ | $-6.92 | $-598.95M ▼ |
| Q2-2025 | $233.7M ▲ | $766.03M ▲ | $-590.77M ▼ | -252.79% ▲ | $-6.92 ▲ | $-514.02M ▲ |
| Q4-2024 | $156.9M ▼ | $709.66M ▲ | $-568.43M ▼ | -362.28% ▼ | $-7.28 ▼ | $-528.45M ▼ |
| Q2-2024 | $823.75M ▲ | $620.7M ▲ | $163M ▲ | 19.79% ▲ | $2.24 ▲ | $229.59M ▲ |
| Q4-2023 | $79.28M | $598.96M | $-523.29M | -660.01% | $-7.2 | $-492.67M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $2.47B ▲ | $3.97B ▲ | $2.63B ▲ | $1.33B ▲ |
| Q2-2025 | $1.66B ▲ | $3.05B ▲ | $2.37B ▲ | $666M ▲ |
| Q4-2024 | $1.24B ▲ | $2.62B ▼ | $2.34B ▲ | $264.19M ▼ |
| Q2-2024 | $1.1B ▲ | $3.11B ▲ | $2.33B ▼ | $766.4M ▲ |
| Q4-2023 | $1.07B | $2.5B | $2.43B | $60.42M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q2-2025 | $-1.18B ▼ | $0 ▼ | $0 ▲ | $0 ▲ | $0 | $0 ▼ |
| Q4-2024 | $-568.43M ▼ | $243.03M ▲ | $-230.76M ▼ | $-82.14M ▼ | $0 ▼ | $235.27M ▲ |
| Q2-2024 | $163M ▲ | $-354.39M ▲ | $-131.28M ▼ | $396.91M ▲ | $952.43M ▲ | $-370.92M ▼ |
| Q4-2023 | $-523.29M ▼ | $-357.61M ▲ | $86.7M ▲ | $-86.88M ▼ | $0 ▲ | $-369.75M ▲ |
| Q2-2023 | $-409.58M | $-368.46M | $-64.77M | $455.63M | $-307.59M | $-413.18M |
What's strong about this company's cash flow?
Last quarter, the company was able to generate positive cash flow from operations and had a solid cash balance. Non-cash charges offset some of the reported losses, suggesting not all losses were real cash outflows.
What are the cash flow concerns?
This quarter, the company generated no cash from operations or investments and ended with zero cash on hand. The sharp drop from positive cash flow to zero is a major red flag for financial health.
5-Year Trend Analysis
A comprehensive look at Ascentage Pharma Group International's financial evolution and strategic trajectory over the past five years.
Key strengths include a robust cash position relative to debt, strong short-term liquidity, and a sizable equity base that supports ongoing operations. On the business side, the company combines real commercial traction in China with a differentiated scientific focus in apoptosis and protein degradation, backed by an extensive patent portfolio and reputable partners. Gross margins on existing revenue are attractive, indicating solid pricing power and manageable direct costs. Together, these factors give Ascentage a meaningful platform from which to pursue its high-ambition oncology strategy.
The most pressing risks stem from very large operating losses, deeply negative cash flow, and a cost structure that far exceeds current revenue. This creates a sustained need for external financing and raises the likelihood of future equity dilution if profitability remains distant. Scientific, clinical, and regulatory uncertainties are substantial, especially given the heavy concentration in oncology and reliance on a relatively small number of key assets. Additional concerns include the high share of intangible assets on the balance sheet, exposure to competitive and pricing pressures, and possible geopolitical or market-access hurdles across regions.
The outlook is that of a high-risk, high-potential biotech: financially stretched but scientifically ambitious, with a credible chance to scale meaningfully if key clinical and commercial milestones are achieved. In the near to medium term, investors and stakeholders should expect continued volatility in earnings and cash flow as the company invests heavily in trials and market expansion. The central variables to watch are clinical data readouts, regulatory decisions, adoption trends for its existing drugs, and its ability to access capital on reasonable terms. If these elements align positively, the current heavy investment phase could lay the groundwork for a more sustainable, value-generating business model; if not, the financial strain could become more problematic over time.
About Ascentage Pharma Group International
https://www.ascentage.cnAscentage Pharma Group International, a clinical-stage biotechnology company, develops therapies for cancers, chronic hepatitis B virus (HBV), and age-related diseases in Mainland China. The company's primary product candidate is HQP1351, a BCR-ABL inhibitor targeting BCR-ABL1 mutants, including those with the T315I mutation.
Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $334.13M ▲ | $906.3M ▲ | $-639.96M ▼ | -191.53% ▲ | $-6.92 | $-598.95M ▼ |
| Q2-2025 | $233.7M ▲ | $766.03M ▲ | $-590.77M ▼ | -252.79% ▲ | $-6.92 ▲ | $-514.02M ▲ |
| Q4-2024 | $156.9M ▼ | $709.66M ▲ | $-568.43M ▼ | -362.28% ▼ | $-7.28 ▼ | $-528.45M ▼ |
| Q2-2024 | $823.75M ▲ | $620.7M ▲ | $163M ▲ | 19.79% ▲ | $2.24 ▲ | $229.59M ▲ |
| Q4-2023 | $79.28M | $598.96M | $-523.29M | -660.01% | $-7.2 | $-492.67M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $2.47B ▲ | $3.97B ▲ | $2.63B ▲ | $1.33B ▲ |
| Q2-2025 | $1.66B ▲ | $3.05B ▲ | $2.37B ▲ | $666M ▲ |
| Q4-2024 | $1.24B ▲ | $2.62B ▼ | $2.34B ▲ | $264.19M ▼ |
| Q2-2024 | $1.1B ▲ | $3.11B ▲ | $2.33B ▼ | $766.4M ▲ |
| Q4-2023 | $1.07B | $2.5B | $2.43B | $60.42M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q2-2025 | $-1.18B ▼ | $0 ▼ | $0 ▲ | $0 ▲ | $0 | $0 ▼ |
| Q4-2024 | $-568.43M ▼ | $243.03M ▲ | $-230.76M ▼ | $-82.14M ▼ | $0 ▼ | $235.27M ▲ |
| Q2-2024 | $163M ▲ | $-354.39M ▲ | $-131.28M ▼ | $396.91M ▲ | $952.43M ▲ | $-370.92M ▼ |
| Q4-2023 | $-523.29M ▼ | $-357.61M ▲ | $86.7M ▲ | $-86.88M ▼ | $0 ▲ | $-369.75M ▲ |
| Q2-2023 | $-409.58M | $-368.46M | $-64.77M | $455.63M | $-307.59M | $-413.18M |
What's strong about this company's cash flow?
Last quarter, the company was able to generate positive cash flow from operations and had a solid cash balance. Non-cash charges offset some of the reported losses, suggesting not all losses were real cash outflows.
What are the cash flow concerns?
This quarter, the company generated no cash from operations or investments and ended with zero cash on hand. The sharp drop from positive cash flow to zero is a major red flag for financial health.
5-Year Trend Analysis
A comprehensive look at Ascentage Pharma Group International's financial evolution and strategic trajectory over the past five years.
Key strengths include a robust cash position relative to debt, strong short-term liquidity, and a sizable equity base that supports ongoing operations. On the business side, the company combines real commercial traction in China with a differentiated scientific focus in apoptosis and protein degradation, backed by an extensive patent portfolio and reputable partners. Gross margins on existing revenue are attractive, indicating solid pricing power and manageable direct costs. Together, these factors give Ascentage a meaningful platform from which to pursue its high-ambition oncology strategy.
The most pressing risks stem from very large operating losses, deeply negative cash flow, and a cost structure that far exceeds current revenue. This creates a sustained need for external financing and raises the likelihood of future equity dilution if profitability remains distant. Scientific, clinical, and regulatory uncertainties are substantial, especially given the heavy concentration in oncology and reliance on a relatively small number of key assets. Additional concerns include the high share of intangible assets on the balance sheet, exposure to competitive and pricing pressures, and possible geopolitical or market-access hurdles across regions.
The outlook is that of a high-risk, high-potential biotech: financially stretched but scientifically ambitious, with a credible chance to scale meaningfully if key clinical and commercial milestones are achieved. In the near to medium term, investors and stakeholders should expect continued volatility in earnings and cash flow as the company invests heavily in trials and market expansion. The central variables to watch are clinical data readouts, regulatory decisions, adoption trends for its existing drugs, and its ability to access capital on reasonable terms. If these elements align positively, the current heavy investment phase could lay the groundwork for a more sustainable, value-generating business model; if not, the financial strain could become more problematic over time.

CEO
Dajun Yang
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