Stock Taper
| DATE | TYPE | RATIO |
|---|---|---|
| 2026-05-11 | Reverse | 1:50 |
| 2022-10-21 | Reverse | 1:50 |
| 2022-08-26 | Forward | 2:1 |
Kala Bio, founded in 2009 in Arlington, MA, develops biopharmaceuticals using proprietary mucus-penetrating nanoparticles, initially targeting ophthalmic diseases. Co-founders include Justin Hanes, Robert S. Langer, and Colin R. Gardner.

KPI-012, a cell-free therapy from mesenchymal stem cell secretomes, targets severe ocular diseases like PCED. It is KALA BIO's lead candidate, reflecting their shift after selling previous assets.
On September 29, 2025, KALA BIO, Inc. announced that its CHASE Phase 2b clinical trial for KPI-012, a treatment for persistent corneal epithelial defect (PCED), failed to meet its primary and key secondary endpoints. This critical setback led the company to cease all development of KPI-012 and its underlying mesenchymal stem cell secretome platform, prompting a significant workforce reduction and a re-evaluation of all strategic options.
Following the failure of its Phase 2b CHASE clinical trial for KPI-012 in September 2025, KALA BIO, Inc. underwent a significant strategic overhaul. This included ceasing the development of KPI-012, restructuring its workforce with a 51% reduction, and appointing investor David E. Lazar as the new CEO and Chairman of the Board, who is leading a strategic re-evaluation of the company's assets and future direction.
Overall rating: B-
| PEER | PRICE | |
|---|---|---|
XTLB | $1.99 | COMPARE |
KTTA | $0.45 | COMPARE |
ENSC | $0.41 | COMPARE |
SNGX | $0.35 | COMPARE |