MAZE
MAZE
Maze Therapeutics, Inc.Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $0 | $37.56M ▲ | $-34.57M ▼ | 0% | $-0.87 ▼ | $-37.56M ▼ |
| Q3-2025 | $0 | $32.97M ▼ | $-30.09M ▲ | 0% | $-0.66 ▲ | $-29.52M ▲ |
| Q2-2025 | $0 | $35.83M ▲ | $-33.68M ▼ | 0% | $-0.77 ▼ | $-33.03M ▲ |
| Q1-2025 | $0 | $35.4M ▲ | $-32.79M ▼ | 0% | $-0.75 ▼ | $-34.72M ▼ |
| Q4-2024 | $0 | $29.73M | $-29.58M | 0% | $-0.11 | $-29.02M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $341.92M ▼ | $397.13M ▼ | $42.16M ▼ | $354.97M ▼ |
| Q3-2025 | $383.94M ▲ | $422.06M ▲ | $42.62M ▲ | $379.44M ▲ |
| Q2-2025 | $264.54M ▼ | $303.52M ▼ | $41.28M ▲ | $262.24M ▼ |
| Q1-2025 | $294.37M ▲ | $332.84M ▲ | $40.77M ▼ | $292.07M ▲ |
| Q4-2024 | $196.81M | $240.54M | $43.64M | $196.9M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $-34.57M ▼ | $-27.73M ▼ | $-103.39M ▼ | $3.59M ▼ | $-127.53M ▼ | $-27.76M ▼ |
| Q3-2025 | $-30.09M ▲ | $-24.64M ▲ | $-66.88M ▼ | $143.76M ▲ | $52.23M ▲ | $-24.71M ▲ |
| Q2-2025 | $-33.68M ▼ | $-30.05M ▼ | $-393K ▼ | $612K ▼ | $-29.83M ▼ | $-30.45M ▼ |
| Q1-2025 | $-32.79M ▼ | $-29.52M ▼ | $-299K ▲ | $127.38M ▲ | $97.56M ▲ | $-29.82M ▼ |
| Q4-2024 | $-29.58M | $-22.45M | $-605K | $70.26M | $47.2M | $-23.06M |
5-Year Trend Analysis
A comprehensive look at Maze Therapeutics, Inc.'s financial evolution and strategic trajectory over the past five years.
Maze combines a strong, cash‑rich balance sheet and very low debt with a focused, genetically driven R&D strategy. Its Compass platform creates a clear scientific narrative and a structured way to generate new drug candidates. The pipeline includes multiple programs in serious diseases with significant unmet needs, and existing partnerships provide external validation and some non‑dilutive funding. Operating costs are concentrated in R&D rather than bloated infrastructure, which aligns spending with the company’s core mission.
At the same time, Maze has no revenue, substantial ongoing losses, and meaningful cash burn, with a track record of cumulative negative earnings. Each major asset carries typical biotech risks: clinical failure, safety concerns, regulatory setbacks, delays, and competition from better‑positioned rivals. The company will likely need additional capital over time, which could depend on market conditions and trial outcomes. Its prospects are also concentrated in a relatively small number of lead programs and in the continued success of the Compass platform, creating a high degree of binary risk around key milestones.
In the near to medium term, Maze is likely to remain loss‑making and cash‑consuming while it advances its pipeline. The company’s future will be shaped primarily by clinical and regulatory milestones—especially for its APOL1 kidney program, dual‑use metabolic candidate, Pompe collaboration, and obesity efforts—along with its ability to maintain a healthy cash runway through partnerships and financings. If its genetics‑first approach continues to yield strong data, Maze could evolve into a partner of choice or a future commercial player in its chosen niches; if key programs disappoint, it may need to rethink its portfolio, cost base, or strategic focus. Uncertainty is high, which is typical for a company at this stage, and outcomes will hinge on scientific execution over the next several years.
About Maze Therapeutics, Inc.
https://www.mazetx.comMaze Therapeutics, Inc., a clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of renal, cardiovascular, related metabolic diseases, and obesity in the United States.
Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $0 | $37.56M ▲ | $-34.57M ▼ | 0% | $-0.87 ▼ | $-37.56M ▼ |
| Q3-2025 | $0 | $32.97M ▼ | $-30.09M ▲ | 0% | $-0.66 ▲ | $-29.52M ▲ |
| Q2-2025 | $0 | $35.83M ▲ | $-33.68M ▼ | 0% | $-0.77 ▼ | $-33.03M ▲ |
| Q1-2025 | $0 | $35.4M ▲ | $-32.79M ▼ | 0% | $-0.75 ▼ | $-34.72M ▼ |
| Q4-2024 | $0 | $29.73M | $-29.58M | 0% | $-0.11 | $-29.02M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $341.92M ▼ | $397.13M ▼ | $42.16M ▼ | $354.97M ▼ |
| Q3-2025 | $383.94M ▲ | $422.06M ▲ | $42.62M ▲ | $379.44M ▲ |
| Q2-2025 | $264.54M ▼ | $303.52M ▼ | $41.28M ▲ | $262.24M ▼ |
| Q1-2025 | $294.37M ▲ | $332.84M ▲ | $40.77M ▼ | $292.07M ▲ |
| Q4-2024 | $196.81M | $240.54M | $43.64M | $196.9M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $-34.57M ▼ | $-27.73M ▼ | $-103.39M ▼ | $3.59M ▼ | $-127.53M ▼ | $-27.76M ▼ |
| Q3-2025 | $-30.09M ▲ | $-24.64M ▲ | $-66.88M ▼ | $143.76M ▲ | $52.23M ▲ | $-24.71M ▲ |
| Q2-2025 | $-33.68M ▼ | $-30.05M ▼ | $-393K ▼ | $612K ▼ | $-29.83M ▼ | $-30.45M ▼ |
| Q1-2025 | $-32.79M ▼ | $-29.52M ▼ | $-299K ▲ | $127.38M ▲ | $97.56M ▲ | $-29.82M ▼ |
| Q4-2024 | $-29.58M | $-22.45M | $-605K | $70.26M | $47.2M | $-23.06M |
5-Year Trend Analysis
A comprehensive look at Maze Therapeutics, Inc.'s financial evolution and strategic trajectory over the past five years.
Maze combines a strong, cash‑rich balance sheet and very low debt with a focused, genetically driven R&D strategy. Its Compass platform creates a clear scientific narrative and a structured way to generate new drug candidates. The pipeline includes multiple programs in serious diseases with significant unmet needs, and existing partnerships provide external validation and some non‑dilutive funding. Operating costs are concentrated in R&D rather than bloated infrastructure, which aligns spending with the company’s core mission.
At the same time, Maze has no revenue, substantial ongoing losses, and meaningful cash burn, with a track record of cumulative negative earnings. Each major asset carries typical biotech risks: clinical failure, safety concerns, regulatory setbacks, delays, and competition from better‑positioned rivals. The company will likely need additional capital over time, which could depend on market conditions and trial outcomes. Its prospects are also concentrated in a relatively small number of lead programs and in the continued success of the Compass platform, creating a high degree of binary risk around key milestones.
In the near to medium term, Maze is likely to remain loss‑making and cash‑consuming while it advances its pipeline. The company’s future will be shaped primarily by clinical and regulatory milestones—especially for its APOL1 kidney program, dual‑use metabolic candidate, Pompe collaboration, and obesity efforts—along with its ability to maintain a healthy cash runway through partnerships and financings. If its genetics‑first approach continues to yield strong data, Maze could evolve into a partner of choice or a future commercial player in its chosen niches; if key programs disappoint, it may need to rethink its portfolio, cost base, or strategic focus. Uncertainty is high, which is typical for a company at this stage, and outcomes will hinge on scientific execution over the next several years.

CEO
Jason V. Coloma
Compensation Summary
(Year )
Upcoming Earnings
ETFs Holding This Stock
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Ratings Snapshot
Rating : C
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Institutional Ownership
TRV GP IV, LLC
Shares:6.07M
Value:$162.78M
FRAZIER LIFE SCIENCES MANAGEMENT, L.P.
Shares:4.57M
Value:$122.4M
DEEP TRACK CAPITAL, LP
Shares:4.25M
Value:$113.8M
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