PLRX
PLRX
Pliant Therapeutics, Inc.Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $0 | $20.71M ▼ | $-23.58M ▲ | 0% | $-0.38 ▲ | $-28.33M ▼ |
| Q3-2025 | $0 | $28.27M ▼ | $-26.3M ▲ | 0% | $-0.43 ▲ | $-23.08M ▲ |
| Q2-2025 | $0 | $45.15M ▼ | $-43.3M ▲ | 0% | $-0.71 ▲ | $-42.04M ▲ |
| Q1-2025 | $0 | $58.94M ▲ | $-56.17M ▼ | 0% | $-0.92 ▼ | $-54.92M ▼ |
| Q4-2024 | $0 | $53.32M | $-49.73M | 0% | $-0.82 | $-48.44M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $190.94M ▼ | $225.23M ▼ | $44.02M ▼ | $181.21M ▼ |
| Q3-2025 | $241.8M ▼ | $276.6M ▼ | $76.29M ▼ | $200.31M ▼ |
| Q2-2025 | $262.87M ▼ | $299.82M ▼ | $79.74M ▼ | $220.08M ▼ |
| Q1-2025 | $305.64M ▼ | $344.77M ▼ | $87.61M ▼ | $257.16M ▼ |
| Q4-2024 | $355.72M | $396.95M | $92.87M | $304.08M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $-23.58M ▲ | $-17.79M ▲ | $1.77M ▼ | $-32.27M ▼ | $-48.29M ▼ | $-17.79M ▲ |
| Q3-2025 | $-26.3M ▲ | $-21.08M ▲ | $27.92M ▼ | $72K ▲ | $6.91M ▲ | $-21.08M ▲ |
| Q2-2025 | $-43.3M ▲ | $-40.6M ▲ | $35.49M ▼ | $0 ▼ | $-5.12M ▼ | $-40.72M ▲ |
| Q1-2025 | $-56.17M ▼ | $-48.86M ▼ | $69.11M ▲ | $498K ▲ | $20.75M ▲ | $-49.13M ▼ |
| Q4-2024 | $-49.73M | $-47.66M | $39.13M | $102K | $-8.43M | $-47.87M |
5-Year Trend Analysis
A comprehensive look at Pliant Therapeutics, Inc.'s financial evolution and strategic trajectory over the past five years.
Key strengths include a strong liquidity position with low leverage, a focused and substantial investment in R&D, and a differentiated scientific platform in integrin biology supported by a major pharmaceutical collaboration. The company’s clean balance sheet, modest fixed asset base, and concentrated spending on development rather than overhead also provide flexibility as it refocuses on oncology.
The primary risks are sustained operating losses, heavy cash burn without current revenue, and high dependence on a few clinical-stage assets, particularly in oncology. The recent failure of a once-flagship fibrosis program highlights clinical and regulatory uncertainty. Over time, the company will likely need additional external funding, which may be influenced by market conditions and perceptions of its pipeline risk and potential.
The outlook is that of a high-risk, high-uncertainty clinical-stage biotech undergoing a strategic pivot. Future prospects hinge on demonstrating meaningful, durable clinical benefit with its lead oncology program, advancing other integrin-based assets, and maintaining sufficient financial runway to reach key data readouts. If clinical results are favorable and capital remains accessible, the current platform could support a more robust, diversified pipeline; if not, financial and strategic options could become more constrained.
About Pliant Therapeutics, Inc.
https://pliantrx.comPliant Therapeutics, Inc., a clinical stage biopharmaceutical company, discovers, develops, and commercializes novel therapies for the treatment of fibrosis and related diseases in the United States. Its lead product candidate is PLN-74809, an oral small-molecule dual selective inhibitor of avß6 and avß1 integrins, which is in three Phase 2a trials.
Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $0 | $20.71M ▼ | $-23.58M ▲ | 0% | $-0.38 ▲ | $-28.33M ▼ |
| Q3-2025 | $0 | $28.27M ▼ | $-26.3M ▲ | 0% | $-0.43 ▲ | $-23.08M ▲ |
| Q2-2025 | $0 | $45.15M ▼ | $-43.3M ▲ | 0% | $-0.71 ▲ | $-42.04M ▲ |
| Q1-2025 | $0 | $58.94M ▲ | $-56.17M ▼ | 0% | $-0.92 ▼ | $-54.92M ▼ |
| Q4-2024 | $0 | $53.32M | $-49.73M | 0% | $-0.82 | $-48.44M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $190.94M ▼ | $225.23M ▼ | $44.02M ▼ | $181.21M ▼ |
| Q3-2025 | $241.8M ▼ | $276.6M ▼ | $76.29M ▼ | $200.31M ▼ |
| Q2-2025 | $262.87M ▼ | $299.82M ▼ | $79.74M ▼ | $220.08M ▼ |
| Q1-2025 | $305.64M ▼ | $344.77M ▼ | $87.61M ▼ | $257.16M ▼ |
| Q4-2024 | $355.72M | $396.95M | $92.87M | $304.08M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $-23.58M ▲ | $-17.79M ▲ | $1.77M ▼ | $-32.27M ▼ | $-48.29M ▼ | $-17.79M ▲ |
| Q3-2025 | $-26.3M ▲ | $-21.08M ▲ | $27.92M ▼ | $72K ▲ | $6.91M ▲ | $-21.08M ▲ |
| Q2-2025 | $-43.3M ▲ | $-40.6M ▲ | $35.49M ▼ | $0 ▼ | $-5.12M ▼ | $-40.72M ▲ |
| Q1-2025 | $-56.17M ▼ | $-48.86M ▼ | $69.11M ▲ | $498K ▲ | $20.75M ▲ | $-49.13M ▼ |
| Q4-2024 | $-49.73M | $-47.66M | $39.13M | $102K | $-8.43M | $-47.87M |
5-Year Trend Analysis
A comprehensive look at Pliant Therapeutics, Inc.'s financial evolution and strategic trajectory over the past five years.
Key strengths include a strong liquidity position with low leverage, a focused and substantial investment in R&D, and a differentiated scientific platform in integrin biology supported by a major pharmaceutical collaboration. The company’s clean balance sheet, modest fixed asset base, and concentrated spending on development rather than overhead also provide flexibility as it refocuses on oncology.
The primary risks are sustained operating losses, heavy cash burn without current revenue, and high dependence on a few clinical-stage assets, particularly in oncology. The recent failure of a once-flagship fibrosis program highlights clinical and regulatory uncertainty. Over time, the company will likely need additional external funding, which may be influenced by market conditions and perceptions of its pipeline risk and potential.
The outlook is that of a high-risk, high-uncertainty clinical-stage biotech undergoing a strategic pivot. Future prospects hinge on demonstrating meaningful, durable clinical benefit with its lead oncology program, advancing other integrin-based assets, and maintaining sufficient financial runway to reach key data readouts. If clinical results are favorable and capital remains accessible, the current platform could support a more robust, diversified pipeline; if not, financial and strategic options could become more constrained.

CEO
Bernard Coulie
Compensation Summary
(Year 2024)
Upcoming Earnings
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Rating : C+
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TANG CAPITAL MANAGEMENT LLC
Shares:6.14M
Value:$8.17M
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