PRLD
PRLD
Prelude Therapeutics IncorporatedIncome Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q3-2025 | $6.5M ▲ | $26.49M ▼ | $-19.73M ▲ | -303.46% ▼ | $-0.26 ▲ | $-19.3M ▲ |
| Q2-2025 | $0 | $32.19M ▼ | $-31.23M ▲ | 0% | $-0.41 ▲ | $-31.76M ▲ |
| Q1-2025 | $0 ▼ | $34.61M ▼ | $-32.09M ▼ | 0% ▲ | $-0.42 ▼ | $-34.17M ▼ |
| Q4-2024 | $4M ▲ | $37.83M ▲ | $-28.73M ▲ | -718.28% ▲ | $-0.38 ▲ | $-33.34M ▲ |
| Q3-2024 | $3M | $37.38M | $-32.27M | -1.08K% | $-0.43 | $-33.97M |
What's going well?
The company finally started bringing in revenue, which is a big milestone. Losses are shrinking, and expenses are coming down, showing better cost control.
What's concerning?
The business is still losing much more money than it brings in, with high R&D spending and no sign of profitability yet. Revenue is just starting and may be unpredictable.
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q3-2025 | $54.96M ▼ | $94.75M ▼ | $36.22M ▼ | $58.53M ▼ |
| Q2-2025 | $73.22M ▼ | $114.92M ▼ | $39.08M ▲ | $75.84M ▼ |
| Q1-2025 | $99.07M ▼ | $141.26M ▼ | $38.08M ▼ | $103.18M ▼ |
| Q4-2024 | $133.61M ▼ | $175.51M ▼ | $44.06M ▲ | $131.46M ▼ |
| Q3-2024 | $153.63M | $197.22M | $40.79M | $156.43M |
What's financially strong about this company?
The company has a high-quality asset base with most assets in cash or equipment, very little debt, and no risky goodwill or intangibles. They can easily pay their bills and have no hidden liabilities.
What are the financial risks or weaknesses?
Cash reserves and equity are dropping quickly, and the company has a long history of losses (deeply negative retained earnings). If this trend continues, financial strength could erode further.
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q3-2025 | $-19.73M ▲ | $-19.11M ▲ | $40.09M ▲ | $-5K ▼ | $21.78M ▲ | $-19.11M ▲ |
| Q2-2025 | $-31.23M ▲ | $-26.07M ▲ | $11.52M ▼ | $37K ▲ | $-14.52M ▼ | $-26.09M ▲ |
| Q1-2025 | $-32.09M ▼ | $-34.23M ▼ | $62.19M ▲ | $-160K ▼ | $27.8M ▲ | $-34.28M ▼ |
| Q4-2024 | $-28.73M ▲ | $-20.74M ▲ | $22.12M ▲ | $-34K ▲ | $1.34M ▲ | $-20.8M ▲ |
| Q3-2024 | $-32.27M | $-27.3M | $10.73M | $-131K | $-16.69M | $-27.36M |
What's strong about this company's cash flow?
Cash burn is shrinking quarter over quarter, and the company boosted its cash reserves by selling investments. No new debt or dilution this quarter.
What are the cash flow concerns?
Core business is still losing money and burning cash. The company is relying on selling investments to survive, and will eventually need to raise more money if losses continue.
Q3 2025 Earnings Call Summary
Read Call Summary5-Year Trend Analysis
A comprehensive look at Prelude Therapeutics Incorporated's financial evolution and strategic trajectory over the past five years.
Key positives include a clearly defined focus on precision oncology, differentiated lead programs targeting well-understood cancer drivers, and a partnership with an established industry player that validates the science and provides non-dilutive support. The company maintains low capital spending needs, limited traditional debt, and a research engine aimed at generating first- or best-in-class candidates. The recent emergence of revenue, while small, signals at least the beginning of commercial or partnership traction.
Major risks center on sustained large losses, accelerating cash burn, and a shrinking balance sheet cushion, all of which create dependence on future financing or deal-making. Clinical and regulatory uncertainty is high, as none of the flagship programs has been tested in humans yet, and setbacks could severely impact perceived value and funding options. Competition from larger pharma and other biotechs in the same pathways adds pressure, while ongoing shareholder dilution and new debt obligations weigh on existing owners.
The forward picture is that of a high-risk, high-uncertainty biotech story: strong scientific ambition and potentially differentiated assets, offset by heavy financial strain and the long, uncertain path to clinical validation and commercialization. If the company can successfully advance its JAK2 and KAT6A programs into and through early trials while managing its cash carefully and leveraging partnerships, its strategic position could improve meaningfully. Conversely, delays, disappointing data, or a difficult funding environment could challenge its ability to fully realize the promise of its current pipeline.
About Prelude Therapeutics Incorporated
https://www.preludetx.comPrelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT543 that is in Phase 1 clinical trials in select solid tumors and myeloid malignancies; and PRT811, which is in Phase 1 clinical trials in solid tumors, including glioblastoma multiforme.
Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q3-2025 | $6.5M ▲ | $26.49M ▼ | $-19.73M ▲ | -303.46% ▼ | $-0.26 ▲ | $-19.3M ▲ |
| Q2-2025 | $0 | $32.19M ▼ | $-31.23M ▲ | 0% | $-0.41 ▲ | $-31.76M ▲ |
| Q1-2025 | $0 ▼ | $34.61M ▼ | $-32.09M ▼ | 0% ▲ | $-0.42 ▼ | $-34.17M ▼ |
| Q4-2024 | $4M ▲ | $37.83M ▲ | $-28.73M ▲ | -718.28% ▲ | $-0.38 ▲ | $-33.34M ▲ |
| Q3-2024 | $3M | $37.38M | $-32.27M | -1.08K% | $-0.43 | $-33.97M |
What's going well?
The company finally started bringing in revenue, which is a big milestone. Losses are shrinking, and expenses are coming down, showing better cost control.
What's concerning?
The business is still losing much more money than it brings in, with high R&D spending and no sign of profitability yet. Revenue is just starting and may be unpredictable.
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q3-2025 | $54.96M ▼ | $94.75M ▼ | $36.22M ▼ | $58.53M ▼ |
| Q2-2025 | $73.22M ▼ | $114.92M ▼ | $39.08M ▲ | $75.84M ▼ |
| Q1-2025 | $99.07M ▼ | $141.26M ▼ | $38.08M ▼ | $103.18M ▼ |
| Q4-2024 | $133.61M ▼ | $175.51M ▼ | $44.06M ▲ | $131.46M ▼ |
| Q3-2024 | $153.63M | $197.22M | $40.79M | $156.43M |
What's financially strong about this company?
The company has a high-quality asset base with most assets in cash or equipment, very little debt, and no risky goodwill or intangibles. They can easily pay their bills and have no hidden liabilities.
What are the financial risks or weaknesses?
Cash reserves and equity are dropping quickly, and the company has a long history of losses (deeply negative retained earnings). If this trend continues, financial strength could erode further.
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q3-2025 | $-19.73M ▲ | $-19.11M ▲ | $40.09M ▲ | $-5K ▼ | $21.78M ▲ | $-19.11M ▲ |
| Q2-2025 | $-31.23M ▲ | $-26.07M ▲ | $11.52M ▼ | $37K ▲ | $-14.52M ▼ | $-26.09M ▲ |
| Q1-2025 | $-32.09M ▼ | $-34.23M ▼ | $62.19M ▲ | $-160K ▼ | $27.8M ▲ | $-34.28M ▼ |
| Q4-2024 | $-28.73M ▲ | $-20.74M ▲ | $22.12M ▲ | $-34K ▲ | $1.34M ▲ | $-20.8M ▲ |
| Q3-2024 | $-32.27M | $-27.3M | $10.73M | $-131K | $-16.69M | $-27.36M |
What's strong about this company's cash flow?
Cash burn is shrinking quarter over quarter, and the company boosted its cash reserves by selling investments. No new debt or dilution this quarter.
What are the cash flow concerns?
Core business is still losing money and burning cash. The company is relying on selling investments to survive, and will eventually need to raise more money if losses continue.
Q3 2025 Earnings Call Summary
Read Call Summary5-Year Trend Analysis
A comprehensive look at Prelude Therapeutics Incorporated's financial evolution and strategic trajectory over the past five years.
Key positives include a clearly defined focus on precision oncology, differentiated lead programs targeting well-understood cancer drivers, and a partnership with an established industry player that validates the science and provides non-dilutive support. The company maintains low capital spending needs, limited traditional debt, and a research engine aimed at generating first- or best-in-class candidates. The recent emergence of revenue, while small, signals at least the beginning of commercial or partnership traction.
Major risks center on sustained large losses, accelerating cash burn, and a shrinking balance sheet cushion, all of which create dependence on future financing or deal-making. Clinical and regulatory uncertainty is high, as none of the flagship programs has been tested in humans yet, and setbacks could severely impact perceived value and funding options. Competition from larger pharma and other biotechs in the same pathways adds pressure, while ongoing shareholder dilution and new debt obligations weigh on existing owners.
The forward picture is that of a high-risk, high-uncertainty biotech story: strong scientific ambition and potentially differentiated assets, offset by heavy financial strain and the long, uncertain path to clinical validation and commercialization. If the company can successfully advance its JAK2 and KAT6A programs into and through early trials while managing its cash carefully and leveraging partnerships, its strategic position could improve meaningfully. Conversely, delays, disappointing data, or a difficult funding environment could challenge its ability to fully realize the promise of its current pipeline.

CEO
Krishna Vaddi
Compensation Summary
(Year 2024)
Upcoming Earnings
ETFs Holding This Stock
Summary
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Ratings Snapshot
Rating : C
Most Recent Analyst Grades
Grade Summary
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Price Target
Institutional Ownership
ORBIMED ADVISORS LLC
Shares:10.91M
Value:$30.11M
BAKER BROS. ADVISORS LP
Shares:10.12M
Value:$27.94M
BOXER CAPITAL, LLC
Shares:1.71M
Value:$4.71M
Summary
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