SLN
SLN
Silence Therapeutics plcIncome Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $34K ▼ | $12.48M ▼ | $-11.77M ▲ | -34.62K% ▼ | $-0.27 ▲ | $-12.35M ▲ |
| Q3-2025 | $159K ▼ | $26.34M ▲ | $-20.96M ▲ | -13.18K% ▼ | $-1.32 ▲ | $-20.8M ▲ |
| Q2-2025 | $224K ▲ | $24.1M ▼ | $-27.35M ▲ | -12.21K% ▲ | $-1.74 ▲ | $-22.49M ▲ |
| Q1-2025 | $142K ▼ | $28.5M ▲ | $-28.53M ▼ | -20.09K% ▼ | $-1.8 ▼ | $-28.27M ▼ |
| Q4-2024 | $24.33M | $25.8M | $14.17M | 58.26% | $0.9 | $7.19M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $85.11M ▼ | $131.44M ▼ | $69.14M ▼ | $62.3M ▼ |
| Q3-2025 | $102.19M ▼ | $146.79M ▼ | $72.73M ▲ | $74.06M ▼ |
| Q2-2025 | $114.16M ▼ | $165.23M ▼ | $71.08M ▼ | $94.16M ▲ |
| Q1-2025 | $136.53M ▼ | $185.3M ▼ | $298.04M ▲ | $-112.74M ▼ |
| Q4-2024 | $147.33M | $202.63M | $68.61M | $134.02M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $-82.17M ▼ | $-17.29M ▼ | $-53.34M ▼ | $-14.09 ▼ | $-70.75M ▼ | $-17.34M ▼ |
| Q3-2025 | $-20.96M ▲ | $-10.89M ▲ | $51.29M ▲ | $0 ▼ | $40.29M ▲ | $-10.89M ▲ |
| Q2-2025 | $-27.35M ▼ | $-21.78M ▼ | $-1.56M ▲ | $1K ▼ | $-23.15M ▲ | $-21.83M ▼ |
| Q1-2025 | $-22.08M ▼ | $-12.31M ▲ | $-44.38M ▼ | $14K ▼ | $-56.44M ▼ | $-12.31M ▲ |
| Q4-2024 | $22.89M | $-22.06M | $49.78M | $1.12M | $59.38M | $-24.92M |
Revenue by Products
| Product | Q1-2025 | Q2-2025 | Q4-2025 |
|---|---|---|---|
Research Collaboration Income | $0 ▲ | $0 ▲ | $0 ▲ |
Q4 2024 Earnings Call Summary
Read Call Summary5-Year Trend Analysis
A comprehensive look at Silence Therapeutics plc's financial evolution and strategic trajectory over the past five years.
Key strengths include a differentiated RNAi platform with clinically validated potential, a pipeline that spans both large cardiovascular markets and rare diseases, and strategic partnerships with major pharma that provide validation and potential non‑dilutive funding. The balance sheet currently shows meaningful cash and minimal debt, allowing management to focus on science. A long history in RNAi and a robust intellectual property portfolio further reinforce its technical foundation.
The main risks are substantial and typical for development‑stage biotech: persistent heavy losses, large negative cash flow, and reliance on future financings or partnership deals to stay funded. Scientific and regulatory uncertainty is high, particularly around pivotal trials for its lead programs. Competitive pressure from larger RNAi players and alternative genetic technologies could erode its opportunity. Additionally, anomalies in the reported balance sheet figures introduce some uncertainty around the precise financial picture and warrant careful scrutiny.
The outlook for SLN is highly dependent on a few key events: successful partnering of its lead cardiovascular program, positive mid‑ and late‑stage clinical data, and continued access to capital. If these elements align, the company could transition from a purely R&D story toward a more mature, royalty‑ and product‑driven model over time. If clinical or funding setbacks occur, the current cash burn and small revenue base leave limited room for error. Overall, SLN represents a classic high‑risk, innovation‑driven biotech profile where outcomes hinge on scientific execution and deal‑making rather than near‑term financial metrics.
About Silence Therapeutics plc
https://www.silence-therapeutics.comSilence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver.
Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $34K ▼ | $12.48M ▼ | $-11.77M ▲ | -34.62K% ▼ | $-0.27 ▲ | $-12.35M ▲ |
| Q3-2025 | $159K ▼ | $26.34M ▲ | $-20.96M ▲ | -13.18K% ▼ | $-1.32 ▲ | $-20.8M ▲ |
| Q2-2025 | $224K ▲ | $24.1M ▼ | $-27.35M ▲ | -12.21K% ▲ | $-1.74 ▲ | $-22.49M ▲ |
| Q1-2025 | $142K ▼ | $28.5M ▲ | $-28.53M ▼ | -20.09K% ▼ | $-1.8 ▼ | $-28.27M ▼ |
| Q4-2024 | $24.33M | $25.8M | $14.17M | 58.26% | $0.9 | $7.19M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $85.11M ▼ | $131.44M ▼ | $69.14M ▼ | $62.3M ▼ |
| Q3-2025 | $102.19M ▼ | $146.79M ▼ | $72.73M ▲ | $74.06M ▼ |
| Q2-2025 | $114.16M ▼ | $165.23M ▼ | $71.08M ▼ | $94.16M ▲ |
| Q1-2025 | $136.53M ▼ | $185.3M ▼ | $298.04M ▲ | $-112.74M ▼ |
| Q4-2024 | $147.33M | $202.63M | $68.61M | $134.02M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $-82.17M ▼ | $-17.29M ▼ | $-53.34M ▼ | $-14.09 ▼ | $-70.75M ▼ | $-17.34M ▼ |
| Q3-2025 | $-20.96M ▲ | $-10.89M ▲ | $51.29M ▲ | $0 ▼ | $40.29M ▲ | $-10.89M ▲ |
| Q2-2025 | $-27.35M ▼ | $-21.78M ▼ | $-1.56M ▲ | $1K ▼ | $-23.15M ▲ | $-21.83M ▼ |
| Q1-2025 | $-22.08M ▼ | $-12.31M ▲ | $-44.38M ▼ | $14K ▼ | $-56.44M ▼ | $-12.31M ▲ |
| Q4-2024 | $22.89M | $-22.06M | $49.78M | $1.12M | $59.38M | $-24.92M |
Revenue by Products
| Product | Q1-2025 | Q2-2025 | Q4-2025 |
|---|---|---|---|
Research Collaboration Income | $0 ▲ | $0 ▲ | $0 ▲ |
Q4 2024 Earnings Call Summary
Read Call Summary5-Year Trend Analysis
A comprehensive look at Silence Therapeutics plc's financial evolution and strategic trajectory over the past five years.
Key strengths include a differentiated RNAi platform with clinically validated potential, a pipeline that spans both large cardiovascular markets and rare diseases, and strategic partnerships with major pharma that provide validation and potential non‑dilutive funding. The balance sheet currently shows meaningful cash and minimal debt, allowing management to focus on science. A long history in RNAi and a robust intellectual property portfolio further reinforce its technical foundation.
The main risks are substantial and typical for development‑stage biotech: persistent heavy losses, large negative cash flow, and reliance on future financings or partnership deals to stay funded. Scientific and regulatory uncertainty is high, particularly around pivotal trials for its lead programs. Competitive pressure from larger RNAi players and alternative genetic technologies could erode its opportunity. Additionally, anomalies in the reported balance sheet figures introduce some uncertainty around the precise financial picture and warrant careful scrutiny.
The outlook for SLN is highly dependent on a few key events: successful partnering of its lead cardiovascular program, positive mid‑ and late‑stage clinical data, and continued access to capital. If these elements align, the company could transition from a purely R&D story toward a more mature, royalty‑ and product‑driven model over time. If clinical or funding setbacks occur, the current cash burn and small revenue base leave limited room for error. Overall, SLN represents a classic high‑risk, innovation‑driven biotech profile where outcomes hinge on scientific execution and deal‑making rather than near‑term financial metrics.

CEO
Iain Gladstone Ross
Compensation Summary
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Rating : C-
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Institutional Ownership
TCG CROSSOVER MANAGEMENT, LLC
Shares:3.03M
Value:$22.63M
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Shares:2.91M
Value:$21.72M
REDMILE GROUP, LLC
Shares:2.16M
Value:$16.15M
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