XERS
XERS
Xeris Biopharma Holdings, Inc.Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $85.81M ▲ | $49.95M ▼ | $11.08M ▲ | 12.91% ▲ | $0.07 ▲ | $14.13M ▲ |
| Q3-2025 | $74.38M ▲ | $56.65M ▲ | $621K ▲ | 0.83% ▲ | $0 ▲ | $11.08M ▲ |
| Q2-2025 | $71.54M ▲ | $52.45M ▼ | $-1.93M ▲ | -2.7% ▲ | $-0.01 ▲ | $8.59M ▲ |
| Q1-2025 | $60.12M ▲ | $54.48M ▲ | $-9.22M ▼ | -15.34% ▼ | $-0.06 ▼ | $1.23M ▼ |
| Q4-2024 | $60.1M | $48.94M | $-5.11M | -8.51% | $-0.03 | $5.72M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $111.04M ▲ | $383.53M ▲ | $369.84M ▼ | $13.69M ▲ |
| Q3-2025 | $91.6M ▲ | $370.19M ▲ | $371.05M ▲ | $-861K ▲ |
| Q2-2025 | $59.28M ▲ | $334.69M ▲ | $353.99M ▲ | $-19.3M ▲ |
| Q1-2025 | $58.44M ▼ | $315.45M ▼ | $350.58M ▼ | $-35.13M ▼ |
| Q4-2024 | $71.62M | $323.06M | $352.68M | $-29.61M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $11.08M ▲ | $20.04M ▲ | $-333K ▼ | $-266K ▼ | $19.44M ▼ | $19.71M ▲ |
| Q3-2025 | $621K ▲ | $18.43M ▲ | $-71K ▲ | $13.85M ▲ | $32.21M ▲ | $18.07M ▲ |
| Q2-2025 | $-1.93M ▲ | $182K ▲ | $-279K ▼ | $942K ▲ | $845K ▲ | $10.04M ▲ |
| Q1-2025 | $-9.22M ▼ | $-10.03M ▼ | $-13K ▼ | $-3.14M ▼ | $-13.18M ▼ | $-10.04M ▼ |
| Q4-2024 | $-5.11M | $1.98M | $10.02M | $398K | $12.39M | $1.75M |
Revenue by Products
| Product | Q1-2025 | Q2-2025 | Q3-2025 | Q4-2025 |
|---|---|---|---|---|
Keveyis | $10.00M ▲ | $10.00M ▲ | $10.00M ▲ | $10.00M ▲ |
Product | $60.00M ▲ | $70.00M ▲ | $70.00M ▲ | $80.00M ▲ |
Product Other | $0 ▲ | $0 ▲ | $0 ▲ | $0 ▲ |
Q4 2025 Earnings Call Summary
Read Call Summary5-Year Trend Analysis
A comprehensive look at Xeris Biopharma Holdings, Inc.'s financial evolution and strategic trajectory over the past five years.
Key strengths include a growing commercial revenue base, a recent transition to positive profitability and cash generation, and a strong short‑term liquidity position with net cash. Technologically, the company benefits from differentiated formulation platforms, a protected patent estate, and a track record of converting that technology into approved, patient‑friendly products. Its focused presence in endocrine and rare disease markets, supported by strategic partnerships, provides a clear strategic identity rather than a scattered portfolio.
Major risks stem from the narrow product base, high dependence on a few therapies, and the inherently uncertain nature of drug development and regulatory approvals. The balance sheet shows significant accumulated losses and a high proportion of intangible assets, which reduce the buffer against adverse events. Operating leverage cuts both ways: high fixed commercial and overhead costs mean that any slowdown in revenue growth could quickly pressure margins and cash flow. Competition, pricing pressure, potential generic entry, and execution risk around XP‑8121 and other pipeline assets add further uncertainty.
The outlook is cautiously constructive: Xeris has demonstrated that its business model can produce revenue growth, operating profits, and free cash flow, while its technology platforms and pipeline offer avenues for further expansion. Management’s expectations for continued strong top‑line growth underscore the potential, but outcomes will hinge on successful scaling of existing products, disciplined cost control, and the clinical and commercial success of XP‑8121 and future partnered programs. Overall, the company appears to be moving from a proof‑of‑concept stage toward a more established specialty‑pharma profile, though execution and external risks remain meaningful and should be monitored closely.
About Xeris Biopharma Holdings, Inc.
https://www.xerispharma.comXeris Biopharma Holdings, Inc., a biopharmaceutical company, engages in developing and commercializing therapies for patient populations in endocrinology, neurology, and gastroenterology.
Income Statement
| Period | Revenue | Operating Expense | Net Income | Net Profit Margin | Earnings Per Share | EBITDA |
|---|---|---|---|---|---|---|
| Q4-2025 | $85.81M ▲ | $49.95M ▼ | $11.08M ▲ | 12.91% ▲ | $0.07 ▲ | $14.13M ▲ |
| Q3-2025 | $74.38M ▲ | $56.65M ▲ | $621K ▲ | 0.83% ▲ | $0 ▲ | $11.08M ▲ |
| Q2-2025 | $71.54M ▲ | $52.45M ▼ | $-1.93M ▲ | -2.7% ▲ | $-0.01 ▲ | $8.59M ▲ |
| Q1-2025 | $60.12M ▲ | $54.48M ▲ | $-9.22M ▼ | -15.34% ▼ | $-0.06 ▼ | $1.23M ▼ |
| Q4-2024 | $60.1M | $48.94M | $-5.11M | -8.51% | $-0.03 | $5.72M |
Balance Statement
| Period | Cash & Short-term | Total Assets | Total Liabilities | Total Equity |
|---|---|---|---|---|
| Q4-2025 | $111.04M ▲ | $383.53M ▲ | $369.84M ▼ | $13.69M ▲ |
| Q3-2025 | $91.6M ▲ | $370.19M ▲ | $371.05M ▲ | $-861K ▲ |
| Q2-2025 | $59.28M ▲ | $334.69M ▲ | $353.99M ▲ | $-19.3M ▲ |
| Q1-2025 | $58.44M ▼ | $315.45M ▼ | $350.58M ▼ | $-35.13M ▼ |
| Q4-2024 | $71.62M | $323.06M | $352.68M | $-29.61M |
Cash Flow Statement
| Period | Net Income | Cash From Operations | Cash From Investing | Cash From Financing | Net Change | Free Cash Flow |
|---|---|---|---|---|---|---|
| Q4-2025 | $11.08M ▲ | $20.04M ▲ | $-333K ▼ | $-266K ▼ | $19.44M ▼ | $19.71M ▲ |
| Q3-2025 | $621K ▲ | $18.43M ▲ | $-71K ▲ | $13.85M ▲ | $32.21M ▲ | $18.07M ▲ |
| Q2-2025 | $-1.93M ▲ | $182K ▲ | $-279K ▼ | $942K ▲ | $845K ▲ | $10.04M ▲ |
| Q1-2025 | $-9.22M ▼ | $-10.03M ▼ | $-13K ▼ | $-3.14M ▼ | $-13.18M ▼ | $-10.04M ▼ |
| Q4-2024 | $-5.11M | $1.98M | $10.02M | $398K | $12.39M | $1.75M |
Revenue by Products
| Product | Q1-2025 | Q2-2025 | Q3-2025 | Q4-2025 |
|---|---|---|---|---|
Keveyis | $10.00M ▲ | $10.00M ▲ | $10.00M ▲ | $10.00M ▲ |
Product | $60.00M ▲ | $70.00M ▲ | $70.00M ▲ | $80.00M ▲ |
Product Other | $0 ▲ | $0 ▲ | $0 ▲ | $0 ▲ |
Q4 2025 Earnings Call Summary
Read Call Summary5-Year Trend Analysis
A comprehensive look at Xeris Biopharma Holdings, Inc.'s financial evolution and strategic trajectory over the past five years.
Key strengths include a growing commercial revenue base, a recent transition to positive profitability and cash generation, and a strong short‑term liquidity position with net cash. Technologically, the company benefits from differentiated formulation platforms, a protected patent estate, and a track record of converting that technology into approved, patient‑friendly products. Its focused presence in endocrine and rare disease markets, supported by strategic partnerships, provides a clear strategic identity rather than a scattered portfolio.
Major risks stem from the narrow product base, high dependence on a few therapies, and the inherently uncertain nature of drug development and regulatory approvals. The balance sheet shows significant accumulated losses and a high proportion of intangible assets, which reduce the buffer against adverse events. Operating leverage cuts both ways: high fixed commercial and overhead costs mean that any slowdown in revenue growth could quickly pressure margins and cash flow. Competition, pricing pressure, potential generic entry, and execution risk around XP‑8121 and other pipeline assets add further uncertainty.
The outlook is cautiously constructive: Xeris has demonstrated that its business model can produce revenue growth, operating profits, and free cash flow, while its technology platforms and pipeline offer avenues for further expansion. Management’s expectations for continued strong top‑line growth underscore the potential, but outcomes will hinge on successful scaling of existing products, disciplined cost control, and the clinical and commercial success of XP‑8121 and future partnered programs. Overall, the company appears to be moving from a proof‑of‑concept stage toward a more established specialty‑pharma profile, though execution and external risks remain meaningful and should be monitored closely.

CEO
John Shannon
Compensation Summary
(Year 2024)
Upcoming Earnings
ETFs Holding This Stock
Summary
Showing Top 3 of 120
Ratings Snapshot
Rating : C
Most Recent Analyst Grades
HC Wainwright & Co.
Buy
Oppenheimer
Outperform
Piper Sandler
Neutral
Leerink Partners
Outperform
Craig-Hallum
Buy
Grade Summary
Showing Top 5 of 5
Price Target
Institutional Ownership
BLACKROCK, INC.
Shares:12.64M
Value:$77.96M
VANGUARD GROUP INC
Shares:11.19M
Value:$69M
BLACKROCK INC.
Shares:10.33M
Value:$63.73M
Summary
Showing Top 3 of 273

