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IONIS PHARMACEUTICALS, INC.
NASDAQ
$61.05
▼ DOWN 2.21% (-1.38)

KEY STATISTICS

Market Cap$10.15 B
52w High$86.74
52w Low$49.13
Dividend Yield—
Frequency—
P/E-35.49
Volume1.85M
Shares Out.166.18M

COMPANY

LEADERSHIP

Brett Monia
CHIEF EXECUTIVE
Brett Monia

COMPENSATION 2026

Salary$1,008,898
Stock Awards$5,627,878
Incentive Plan Pay$0
All Other Comp.$52,889
Total$15,400,343

ABOUT

SECTOR
Healthcare
WENT PUBLIC
May 17, 1991
METHOD OF GOING PUBLIC
IPO
FULL TIME EMPLOYEES
1,480

PRICE TARGET

Target High$115.00
Target Low$69.00
Target Median$90.00
Target Consensus$93.36

UPCOMING EARNINGS

DateNov 4, 2026
DayWednesday
Rev. Est.$181.78M
NOV
4
WED

PRICE

$61.05 ▼ DOWN 2.21% (−$1.38)
$60.75$61.00$61.25$61.509:32 AM10:37 AM11:41 AM12:45 PM1:50 PM2:55 PM3:59 PM61.05

About Ionis Pharmaceuticals, Inc.

https://www.ionis.com ↗

Ionis Pharmaceuticals develops RNA-targeted therapeutics for various diseases, including SMA, amyloidosis, hypertriglyceridemia, and ALS, with collaborations involving major biotech and pharma companies.

INDUSTRY

Biotechnology

A PRODUCT IONIS PHARMACEUTICALS, INC. IS KNOWN FOR

DAWNZERA™ (donidalorsen)
DAWNZERA™ (donidalorsen)

DAWNZERA™ is a self-administered RNA-targeted therapy approved in August 2025 for preventing hereditary angioedema in patients 12+, marking Ionis' second independent product launch and a key step in its strategy to commercialize wholly-owned medic...

COMPETITORS

COMPETITOR
BCRX COMPARE
KA KALV COMPARE
NTLA COMPARE
PHAR COMPARE
PHVS COMPARE

Revenue by Products

IconPRODUCTQ3-2025Q4-2025Q1-2026Q2-2026
Commercial Member$115.6M $217.49M ▲$107.81M ▼$118.62M ▲
Royalty$75.69M $75.72M ▲$58.32M ▼$75.96M ▲
Product$31.79M $64.25M ▲$42.95M ▼$31.14M ▼

ETFS HOLDING THIS STOCK

ETFS HOLDING
219
LISTED HERE
26
RANKED BY POSITION SIZE
VTI
0.01% · 5.0M
XBI
0.76% · 1.4M
CGGR
0.32% · 1.3M
IBB
0.71% · 1.2M
SCHA
0.21% · 785.2K
ARKG
1.82% · 620.9K
FXH
1.01% · 188.3K
NUSC
0.71% · 166.5K
QMOM
2.22% · 153.0K
TMSL
0.28% · 133.7K
PRFZ
0.24% · 110.5K
FSMD
0.23% · 95.5K
BBMC
0.21% · 74.2K
JHMM
0.06% · 60.9K
SMOT
1.03% · 54.7K
LABU
0.52% · 52.5K
TMFM
2.53% · 49.8K
CO
COPY
0.63% · 43.6K
XCHA.L
0.12% · 37.0K
PB
PBPH
0.21% · 34.6K
BKMC
0.25% · 27.0K
TSCM
3.37% · 24.9K
BBP
1.05% · 20.0K
ZUH.TO
0.89% · 19.5K
VALT
0.44% · 18.8K
NBCR
0.11% · 15.5K

INSTITUTIONAL OWNERSHIP

SHARES OWNED
94.07%
HOLDERS
729
TOP 12 OF 729 · RANKED BY POSITION SIZE
Dld Asset Management, LP
25.0M sh · $34.63M
Fmr LLC
24.6M sh · $1.95B
Capital World Investors
21.7M sh · $1.72B
Vanguard Group Inc
16.5M sh · $1.08B
T. Rowe Price Investment Management, Inc.
13.2M sh · $860.73M
Blackrock, Inc.
10.7M sh · $848.77M
Blackrock Inc.
10.3M sh · $491.9M
Bb Biotech AG
7.7M sh · $627.04M
Wellington Management Group Llp
7.7M sh · $606.68M
Lombard Odier Asset Management (Europe) Ltd
6.5M sh · $8.96M
Two Sigma Investments, LP
6.3M sh · $495.75M
Bellevue Group AG
6.2M sh · $408.51M

RATINGS SNAPSHOT

Overall rating: D+

DCFROEROAD/EP/EP/B
Discounted Cash Flow1
Return On Equity1
Return On Assets1
Debt To Equity1
Price To Earnings1
Price To Book1
Overall Score1

TRADES BY CONGRESS

HOUSE TRADES
Ro Khanna
Ro Khanna
Sale
2023-03-14
 Daniel Goldman
Daniel Goldman
Sale (Full)
2023-03-06
 Donna Shalala
Donna Shalala
Sale (Full)
2019-06-24
SENATE TRADES
Sheldon Whitehouse
Sheldon Whitehouse
Sale (Full)
2016-01-20

INSIDER TRADES

★
DIRECTOR
Hayden Michael R
Purchase · 15.0K shares
2026-07-30
★
DIRECTOR
Hayden Michael R
Purchase · 5.0K shares
2026-07-31
★
DIRECTOR
HANTSON LUDWIG
Purchase · 3.4K shares
2026-07-15
★
DIRECTOR
BERTHELSEN SPENCER R
Sale · 5.2K shares
2026-07-15

MOST RECENT ANALYST GRADES

GRADE SUMMARY
BUY 8
OVERWEIGHT 5
OUTPERFORM 3
MARKET PERFORM 1
PEER PERFORM 1
NEUTRAL 1
HOLD 1
STRONG BUY 1
21 GRADES IN THE LAST 12 MONTHS
BMO Capital MARKET PERFORM JP Morgan OVERWEIGHT HC Wainwright & Co. BUY Wells Fargo OVERWEIGHT Guggenheim BUY Wolfe Research PEER PERFORM RBC Capital OUTPERFORM Morgan Stanley OVERWEIGHT

SECTORS PEERS

PEERPRICE
MRNA$137.99COMPARE
RVMD$207.88COMPARE
ROIV$34.71COMPARE
GH$161.50COMPARE
ASND$247.91COMPARE
BBIO$76.60COMPARE
EXEL$54.45COMPARE
BMRN$64.67COMPARE