SIREN, L.L.C.
Latest 13F filing data - Q3 2025
Holdings (Top positions)
| Stock | Ticker | ||
|---|---|---|---|
 | IRON | 913K | $60.36M |
 | DNLI | 822K | $11.93M |
 | XENE | 813K | $32.63M |
 | UPB | 788K | $14.83M |
 | NAMS | 766K | $21.78M |
 | SGMT | 725K | $4.97M |
 | FHTX | 721K | $3.52M |
 | PEPG | 700K | $3.23M |
 | AVBP | 700K | $12.91M |
 | LXEO | 603K | $4.01M |
 | RAPT | 580K | $14.97M |
 | RNAC | 563K | $5.76M |
 | RYTM | 500K | $50.49M |
 | SLNO | 467K | $31.59M |
 | KRRO | 419K | $20.06M |
 | BIOA | 382K | $2.25M |
 | SYRE | 369K | $6.18M |
 | TENX | 352K | $2.68M |
 | SION | 325K | $9.56M |
 | KLRS | 318K | $1.84M |
Disc Medicine, Inc.
IRON
Shares Held
913K
Value
$60.36M
Denali Therapeutics Inc.
DNLI
Shares Held
822K
Value
$11.93M
Xenon Pharmaceuticals Inc.
XENE
Shares Held
813K
Value
$32.63M
Upstream Bio, Inc.
UPB
Shares Held
788K
Value
$14.83M
NewAmsterdam Pharma Company N.V.
NAMS
Shares Held
766K
Value
$21.78M
Sagimet Biosciences Inc.
SGMT
Shares Held
725K
Value
$4.97M
Foghorn Therapeutics Inc.
FHTX
Shares Held
721K
Value
$3.52M
PepGen Inc.
PEPG
Shares Held
700K
Value
$3.23M
ArriVent BioPharma, Inc. Common Stock
AVBP
Shares Held
700K
Value
$12.91M
Lexeo Therapeutics, Inc. Common Stock
LXEO
Shares Held
603K
Value
$4.01M
RAPT Therapeutics, Inc.
RAPT
Shares Held
580K
Value
$14.97M
Cartesian Therapeutics, Inc.
RNAC
Shares Held
563K
Value
$5.76M
Rhythm Pharmaceuticals, Inc.
RYTM
Shares Held
500K
Value
$50.49M
Soleno Therapeutics, Inc.
SLNO
Shares Held
467K
Value
$31.59M
Korro Bio, Inc.
KRRO
Shares Held
419K
Value
$20.06M
BioAge Labs, Inc.
BIOA
Shares Held
382K
Value
$2.25M
Spyre Therapeutics, Inc.
SYRE
Shares Held
369K
Value
$6.18M
Tenax Therapeutics, Inc.
TENX
Shares Held
352K
Value
$2.68M
Sionna Therapeutics, Inc.
SION
Shares Held
325K
Value
$9.56M
Kalaris Therapeutics Inc
KLRS
Shares Held
318K
Value
$1.84M